Ero sivun ”Serotoniinireseptori” versioiden välillä

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#OHJAUS [[Serotoniini]]
[[Tiedosto:Serotonin.svg|thumb|250px|[[Serotoniini]].}}
'''Serotoniinireseptori''' eli '''5-HT-reseptori''' on monien eliölajien, muun muassa ihmisen [[Reseptori (biokemia)|reseptori]], johon [[Hermoston välittäjäaine|välittäjäaine]] [[serotoniini]] voi kiinnittyä. Reseptoreita on seitsemää tyyppiä, 5-HT<sub>1–7</sub>, jotka jakautuvat edelleen lukuisiin alatyyppeihin.

Lukuunottamatta [[5-HT3-reseptori|5-HT<sub>3</sub>-reseptoria]], joka on [[ionikanavareseptori]], kaikki muut serotoniinireseptorit ovat [[G-proteiinikytkentäinen reseptori|G-proteiinikytkentäisiä reseptoreja]], jotka aktivoivat [[Toisiolähetti|toisiolähettejä]] hermosolun sisällä, jotta viesti välittyy eteenpäin.

=== Tyypit ===

{| class="wikitable"
| '''Tyyppi''' || '''Toimintatyyppi''' || '''Mekanismi''' || '''Vaikutustapa'''
|-
| '''[[5-HT1-reseptori|5-HT<sub>1</sub>]]''' || [[Gi-alfa-alayksikkö|G<sub>i</sub>/G<sub>o</sub>]]-proteiinikytkentäinen. || Solun [[cAMP]]-tason vähentäminen. || Estävä
|-
| '''[[5-HT2-reseptori|5-HT<sub>2</sub>]]''' || [[Gq-proteiini|G<sub>q</sub>/G<sub>11</sub>]]-proteiinikytkentäinen. || Solun [[inositolitrifosfaatti|IP<sub>3</sub>]]- ja [[Diglyseridi|DAG]]-tasojen lisääminen. || Kiihdyttävä
|-
| '''[[5-HT3-reseptori|5-HT<sub>3</sub>]]''' || Ligandiporttinen [[Natrium|Na<sup>+</sup>]] ja [[Kalium|K<sup>+</sup>]] -[[Ionikanava|kationikanava]]. || [[Plasmakalvo]]n [[Depolarisaatio|depolarisointi]]. || Kiihdyttävä
|-
| '''[[5-HT4-reseptori|5-HT<sub>4</sub>]]''' || [[G(s)alfa|G<sub>s</sub>]]-proteiinikytkentäinen. || Solun [[cAMP]]-tason lisääminen. || Kiihdyttävä
|-
| '''[[5-HT5A-reseptori|5-HT<sub>5</sub>]]''' || [[Gi-alfa-alayksikkö|G<sub>i</sub>/G<sub>o</sub>]]-proteiinikytkentäinen.<ref name="pmid9865521">{{cite journal | author = Francken BJ, Jurzak M, Vanhauwe JF, Luyten WH, Leysen JE. | title = The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells. | journal = Eur J Pharmacol. | volume = 361 | issue = 2–3 | pages = 299–309 | year = 1998 | pmid = 9865521 | doi = 10.1016/S0014-2999(98)00744-4 }}</ref> || Solun [[cAMP]]-tason vähentäminen. || Estävä
|-
| '''[[5-HT6-reseptori|5-HT<sub>6</sub>]]''' || [[G(s)alfa|G<sub>s</sub>]]-proteiinikytkentäinen. || Solun [[cAMP]]-tason lisääminen. || Kiihdyttävä
|-
| '''[[5-HT7-reseptori|5-HT<sub>7</sub>]]''' || [[G(s)alfa|G<sub>s</sub>]]-proteiinikytkentäinen. || Solun [[cAMP]]-tason lisääminen. || Kiihdyttävä
|}

=== Alatyypit ===

Päätyypit jakautuvat edelleen alatyyppeihin, joilla on tiettyjä erityisominaisuuksia:<ref name="urlSerotonin Receptor Subtypes and Ligands">{{cite web | url = http://www.acnp.org/g4/GN401000039/Ch039.html | title = Serotonin Receptor Subtypes and Ligands | accessdate = 2008-04-11 | author = Glennon RA, Dukat M, Westkaemper RB | authorlink = | coauthors = | date = 2000-01-01 | work = | publisher = American College of Neurophyscopharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}</ref><ref name="urlIUPHAR DATABASE | 5-HYDROXYTRYPTAMINE RECEPTORS">{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1288 | title = 5-Hydroxytryptamine Receptors | accessdate = 2008-04-11 | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Receptor Database | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}</ref><ref name="Wesolowska_2002">{{cite journal |author=Wesolowska A |title=In the search for selective ligands of 5-HT<sub>5</sub>, 5-HT<sub>6</sub> and 5-HT<sub>7</sub> serotonin receptors |journal=Polish Journal of Pharmacology |volume=54 |issue=4 |pages=327–41 |year=2002 |pmid=12523486 |url=http://www.if-pan.krakow.pl/pjp/pdf/2002/4_327.pdf|format=PDF}}</ref>

{| class="wikitable"
|colspan=6| '''Yleiskatsaus serotoniinireseptoreista'''
|-
! Reseptori
! Geeni(t)
! Sijaintipaikat
! Tehtävä
! [[Agonisti]]t
! [[Antagonisti (lääketiede)|Antagonistit]]
|-
! [[5-HT1A-reseptori|5-HT<sub>1A</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR1A HTR1A]
|
* Verisuonet
* Keskushermosto
|
* Riippuvuus <ref name="pmid7862892">{{cite journal | author = Tomkins DM, Higgins GA, Sellers EM | title = Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake | journal = Psychopharmacology (Berl). | volume = 115 | issue = 1–2 | pages = 173–9 | year = 1994 | pmid = 7862892 | doi = 10.1007/BF02244769 }}</ref><ref name="pmid17316955">{{cite journal | author = Müller CP, Carey RJ, Huston JP, De Souza Silva MA | title = Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors | journal = Prog Neurobiol. | volume = 81 | issue = 3 | pages = 133–78 | year = 2007 | pmid = 17316955 | doi = 10.1016/j.pneurobio.2007.01.001 }}</ref><ref name="pmid15713268">{{cite journal | author = Carey RJ, DePalma G, Damianopoulos E, Shanahan A, Müller CP, Huston JP | title = Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects | journal = Brain Res. | volume = 1034 | issue = 1–2 | pages = 162–71 | year = 2005 | pmid = 15713268 | doi = 10.1016/j.brainres.2004.12.012 }}</ref>
* Aggressio<ref name="pmid16310183">{{cite journal | author = de Boer SF, Koolhaas JM | title = 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis | journal = Eur J Pharmacol. | volume = 526 | issue = 1–3 | pages = 125–39 | year = 2005 | pmid = 16310183 | doi = 10.1016/j.ejphar.2005.09.065 }}</ref>
* Hätääntyneisyys<ref name="pmid9724773">{{cite journal | author = Parks CL, Robinson PS, Sibille E, Shenk T, Toth M | title = Increased anxiety of mice lacking the serotonin1A receptor | journal = Proc Natl Acad Sci U S A. | volume = 195 | issue = 18 | pages = 10734–9 | year = 1998 | pmid = 9724773 | pmc = 27964 | doi=10.1073/pnas.95.18.10734}}</ref>
* Ruokahalu<ref name="pmid17609739">{{cite journal | author = Ebenezer IS, Arkle MJ, Tite RM | title = 8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors | journal = Methods Find Exp Clin Pharmacol. | volume = 29 | issue = 4 | pages = 269–72 | year = 1998 | pmid = 17609739 | doi = 10.1358/mf.2007.29.4.1075362 }}</ref>
* Verenpaine<ref name="pmid2842163">{{cite journal | author = Wouters W, Tulp MT, Bevan P | title = Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors | journal = Eur J Pharmacol. | volume = 149 | issue = 3 | pages = 213–23 | year = 1998 | pmid = 2842163 | doi = 10.1016/0014-2999(88)90651-6 }}</ref><ref name="pmid18667366">{{cite journal | author = Horiuchi J, McDowall LM, Dampney RA | title = Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation | journal = Auton Neurosci. | volume = 142 | issue = 1–2 | pages = 71–6 | year = 2008 | pmid = 18667366 | doi = 10.1016/j.autneu.2008.06.004 }}</ref>
* Sydän<ref name="pmid15802554">{{cite journal | author = Nalivaiko E, Ootsuka Y, Blessing WW. | title = Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits | journal = Am J Physiol Regul Integr Comp Physiol. | volume = 289 | issue = 2 | pages = R596–R604 | year = 2005 | pmid = 15802554 | doi = 10.1152/ajpregu.00845.2004 }}</ref>
* Oksentaminen<ref name="pmid8013549">{{cite journal | author = Lucot JB. | title = Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin | journal = Eur J Pharmacol. | volume = 253 | issue = 1–2 | pages = 53–60 | year = 1994 | pmid = 8013549 | doi = 10.1016/0014-2999(94)90756-0 }}</ref>
* Sydämen lyöntitiheys<ref name="pmid2842163"/><ref name="pmid18667366"/>
* Impulsiivisuus<ref name="pmid15688093">{{cite journal | author = Winstanley CA, Theobald DE, Dalley JW, Robbins TW. | title = Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders | journal = Neuropsychopharmacology. | volume = 30 | issue = 4 | pages = 669–682 | year = 2005 | pmid = 15688093 | doi = 10.1038/sj.npp.1300610 }}</ref>
* Muisti<ref name="pmid18394726">{{cite journal | author = Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O | title = The role of 5-HT(1A) receptors in learning and memory | journal = Behav Brain Res. | volume = 195 | issue = 1 | pages = 54–77 | year = 2008 | pmid = 18394726 | doi = 10.1016/j.bbr.2008.02.023 }}</ref><ref name="pmid12562581">{{cite journal | author = Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K | title = Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory | journal = Am J Psychiatry | volume = 160 | issue = 2 | pages = 334–40 | year = 2003 | pmid = 12562581 | doi = 10.1176/appi.ajp.160.2.334 }}</ref>
* Mieliala<ref name="pmid2883013">{{cite journal | author = Kennett GA, Dourish CT, Curzon G | title = Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression | journal = Eur J Pharmacol. | volume = 134 | issue = 3 | pages = 265–74 | year = 1987 | pmid = 2883013 | doi = 10.1016/0014-2999(87)90357-8 }}</ref>
* Pahoinvointi<ref name="pmid8013549"/>
* Haitalliset ärsykkeet<ref name="pmid12595749">{{cite journal | author = Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC. | title = Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain | journal = Pharmacology. | volume = 67 | issue = 4 | pages = 182–194 | year = 2003 | pmid = 12595749 | doi = 10.1159/000068404 }}</ref>
* Siittimen erektio<ref name="pmid9085055">{{cite journal | author = Millan MJ, Perrin-Monneyron S | title = Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors | journal = Eur J Pharmacol. | volume = 321 | issue = 3 | pages = 11–3 | year = 1997 | pmid = 9085055 | doi=10.1016/S0014-2999(97)00050-2}}</ref>
* Pupillin laajeneminen<ref name="pmid8982715">{{cite journal | author = Prow MR, Martin KF, Heal DJ | title = 8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation | journal = Eur J Pharmacol. | volume = 317 | issue = 1 | pages = 21–8 | year = 1996 | pmid = 8982715 | doi = 10.1016/S0014-2999(96)00693-0 }}</ref>
* Hengitys<ref name="pmid16166206">{{cite journal | author = Meyer LC, Fuller A, Mitchell D | title = Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats | journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | volume = 290 | issue = 2 | pages = R405–13 | year = 2006 | month = February | pmid = 16166206 | doi = 10.1152/ajpregu.00440.2005 | url = | issn = }}</ref>
* Seksuaalinen käytös<ref name="pmid11965359">{{cite journal | author = Popova NK, Amstislavskaya TG | title = Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice | journal = Psychoneuroendocrinology | volume = 27 | issue = 5 | pages = 609–18 | year = 2002 | pmid = 11965359 | doi = 10.1016/S0306-4530(01)00097-X }}</ref>
* Uni<ref name="pmid10607047">{{cite journal | author = Monti JM, Jantos H | title = Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat | journal = J Sleep Res. | volume = 1 | issue = 3 | pages = 169–175 | year = 1992 | pmid = 10607047 | doi = 10.1111/j.1365-2869.1992.tb00033.x }}</ref>
* Sosiaalisuus<ref name="pmid17383105">{{cite journal | author = Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS | title = A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy") | journal = Neuroscience | volume = 146 | issue = 2 | pages = 509–14 | year = 2007 | pmid = 17383105 | doi = 10.1016/j.neuroscience.2007.02.032 }}</ref>
* Lämmönsäätely<ref name="pmid2951611">{{cite journal | author = Gudelsky GA, Koenig JI, Meltzer HY | title = Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors | journal = Neuropharmacology | volume = 25 | issue = 12 | pages = 1307–13 | year = 1986 | pmid = 2951611 | doi = 10.1016/0028-3908(86)90101-2 }}</ref>
* Verisuonten supistuminen<ref name="pmid16455061">{{cite journal | author = Ootsuka Y, Blessing WW. | title = Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits | journal = Brain Res. | volume = 1073-1074 | pages = 252–61 | year = 2006 | pmid = 16455061 | doi = 10.1016/j.brainres.2005.12.031 }}</ref>
| <!--5-HT1A AGONISTs-->
* [[5-Karboksamiditryptamiini|5-CT]]
* [[8-OH-DPAT]]
* [[Aripipratsoli]]
* [[Buspironi]]<ref name=pharmamotion>[http://pharmamotion.com.ar/serotonin-5ht-receptors-agonists-antagonist/ pharmamotion.com > Serotonin (5-HT): receptors, agonists and antagonists] By Flavio Guzmán, M.D. on 9/08/09</ref> ([[anksiolyytti]] ja [[antidepressantti]])<ref name=pharmamotion/>
* [[Kannabidioli]]
* [[Klotsapiini]]
* [[Dihydroergotamiini]]
* [[Eltopratsiini]]
* [[Ergotamiini]]
* [[Flesinoksaani]]
* [[Flibanseriini]]
* [[Gepironi]]
* [[Ipsapironi]]
* [[Metysergidi]]
* [[Nefatsodoni]]
* [[Psilosiini]]
* [[Ketiapiini]]
* [[RU 24969]]
* [[Tandospironi]]
* [[Tratsodoni]]
* [[Urapidiili]]
* [[Ksaliprodeeni]]
* [[Johimbiini]]
* [[Tsiprasidoni]]
|<!--5-HT1A ANTAGONISTs-->
* [[Alprenololi]]
* [[Asenapiini]]
* [[BMY 7378]]
* [[Syanopindololi]]
* [[Jodosyanopindololi]]
* [[Lekotsotaani]]
* [[Metiotepiini]]
* [[NAN-190]]
* [[Nebivololi]]
* [[Oksprenololi]]
* [[Pindololi]]
* [[Propanololi]]
* [[Robaltsotaani]]
* [[S15535]]
* [[Spiperoni]]
* [[TFMPP]]
* [[UH-301]]
* [[WAY-100,135]]
* [[WAY-100,635]]
* [[Mefway]]
|-
! [[5-HT1B-reseptori|5-HT<sub>1B</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR1B HTR1B]
|
* Verisuonet
* Keskushermosto
|
* Riippuvuus <ref name="pmid10027505">{{cite journal | author = Harrison AA, Parsons LH, Koob GF, Markou A | title = RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist | journal = Psychopharmacology (Berl). | volume = 141 | issue = 3 | pages = 242–50 | year = 1999 | pmid = 10027505 | doi = 10.1007/s002130050831 }}</ref>
* Aggressio<ref name="pmid16310183"/>
* Hätääntyneisyys<ref name="pmid15720791">{{cite journal | author = Chojnacka-Wójcik E, Klodzinska A, Tatarczynska E | title = The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action | journal = J Pharm Pharmacol. | volume = 57 | issue = 2 | pages = 253–7 | year = 2005 | pmid = 15720791 | doi = 10.1211/0022357055399 }}</ref><ref name="pmid11888549">{{cite journal | author = Lin D, Parsons LH | title = Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze | journal = Pharmacol Biochem Behav. | volume = 71 | issue = 4 | pages = 581–7 | year = 2002 | pmid = 11888549 | doi = 10.1016/S0091-3057(01)00712-2 }}</ref><ref name="pmid15577451">{{cite journal | author = Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E | title = Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression | journal = Behav Pharmacol. | volume = 15 | issue = 8 | pages = 523–34 | year = 2004 | pmid = 15577451 | doi = 10.1097/00008877-200412000-00001 }}</ref>
* Oppiminen<ref name="pmid18394658">{{cite journal | author = Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO | title = Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission | journal = Neuropharmacology | volume = 54 | issue = 7 | pages = 1041–50 | year = 2008 | pmid = 18394658 | doi = 10.1016/j.neuropharm.2008.02.007 }}</ref>
* Liikkeet<ref name="pmid10454466">{{cite journal | author = McCreary AC, Bankson MG, Cunningham KA | title = Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors | journal = J Pharmacol Exp Ther. | volume = 290 | issue = 3 | pages = 965–73 | year = 1999 | pmid = 10454466 }}</ref>
* Muisti<ref name="pmid18394658"/>
* Mieliala<ref name="pmid15577451"/>
* Siittimen erektio<ref name="pmid9085055"/>
* Seksuaalinen käytös<ref name="pmid11965359"/>
* Verisuonten supistuminen
|<!--5-HT1B AGONISTs-->
* [[5-Karboksamiditryptamiini|5-CT]]
* [[CP-93,129]]
* [[CP-94,253]]
* [[Dihydroergotamiini]]
* [[Eltopratsiini]]
* [[Ergotamiini]]
* [[Metysergidi]]
* [[RU 24969]]
* [[TFMPP]]
* [[Triptaani]]t<ref name=pharmamotion/> ([[antimigraine]]<ref name=pharmamotion/>)
** [[Tsolmitriptaani]]
** [[Eletriptaani]]
** [[Sumatriptaani]]
|<!--5-HT1B ANTAGONISTs-->
* [[Alprenololi]]
* [[AR-A000002]]
* [[Asenapiini]]
* [[Syanopindololi]]
* [[GR 127935]]
* [[Jodosyanopindololi]]
* [[Isamoltaani]]
* [[Metergoliini]]
* [[Metiotepiini]]
* [[Oksprenololi]]
* [[Pindololi]]
* [[Propanololi]]
* [[SB-216,641]]
* [[Johimbiini]]
|-
! [[5-HT1D-reseptori|5-HT<sub>1D</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR1D HTR1D]
|
* Verisuonet
* Keskushermosto
|
* Hätääntyneisyys<ref name="pmid15820416">{{cite journal | author = Amital D, Fostick L, Sasson Y, Kindler S, Amital H, Zohar J | title = Anxiogenic effects of Sumatriptan in panic disorder: a double-blind, placebo-controlled study | journal = Eur Neuropsychopharmacol. | volume = 15 | issue = 3 | pages = 279–82 | year = 2005 | pmid = 15820416 | doi = 10.1016/j.euroneuro.2004.12.002 }}</ref><ref name="pmid8736648">{{cite journal | author = Feuerstein TJ, Hüring H, van Velthoven V, Lücking CH, Landwehrmeyer GB | title = 5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex | journal = Neurosci Lett. | volume =209 | issue = 3 | pages = 210–4 | year = 1996 | pmid = 8736648 | doi = 10.1016/0304-3940(96)12637-9 }}</ref>
* Liikkeet<ref name="pmid10454466"/>
* Verisuonten supistuminen
|<!--5-HT1D AGONISTs-->
* [[5-Karboksamiditryptamiini|5-CT]]
* [[Dihydroergotamiini]]
* [[Ergotamiini]]
* [[Metysergidi]]
* [[Triptaani]]t<ref name=pharmamotion/> ([[antimigraine]]<ref name=pharmamotion/>)
** [[Almotriptaani]]
** [[Eletriptaani]]
** [[Frovatriptaani]]
** [[Naratriptaani]]
** [[Ritsatriptaani]]
** [[Sumatriptaani]]
** [[Tsolmitriptaani]]
* [[Johimbiini]]
|<!--5-HT1D ANTAGONISTs-->
* [[BRL-15572]]
* [[GR 127935]]
* [[Ketanseriini]]
* [[Metergoliini]]
* [[Metiotepinini]]
* [[Isojohimbiini]]
* [[Ritanseriini]]
|-
! [[5-HT1e-reseptori|5-HT<sub>1e</sub>]] otaksuttu olemassaolevaksi
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR1E HTR1E]
|
* Verisuonet
* Keskushermosto
|
|
* [[Eletriptaani]]
* [[Metysergidi]]
* [[Tryptamiini]]
|
* [[Metiotepiini]]
|-
! [[5-HT1F-reseptori|5-HT<sub>1F</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR1F HTR1F]
|
* Keskushermosto
|
* Migreeni
|<!--5-HT1F AGONISTs-->
* LY334370
* COL-144
|-
! [[5-HT2A-reseptori|5-HT<sub>2A</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR2A HTR2A]
|
* Verisuonet
* Keskushermosto
* Ruoansulatuskanava
* Verihiutaleet
* Ääreishermosto
* Sileä lihaskudos
|
* Riippuvuus (mahdollisesti moduloiva) <ref name="Bubar">[http://www.ncbi.nlm.nih.gov/pubmed/17017968] Bubar MJ, Cunningham KA. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem. 2006;6(18):1971-85.</ref>
* Hätääntyneisyys<ref name="pmid9539263">{{cite journal | author = Schreiber R, Melon C, De Vry J | title = The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test | journal = Psychopharmacology (Berl). | volume = 135 | issue = 4 | pages = 383–91 | year = 1998 | pmid = 9539263 | doi = 10.1007/s002130050526 }}</ref>
* Ruokahalu
* Kognitio
* Mielikuvitus
* Oppiminen
* Muisti
* Mieliala
* Havaintokyky
* Seksuaalinen käytös<ref name="pmid12097814">{{cite journal | author = Popova NK, Amstislavskaya TG | title = 5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female | journal = Neuroendocrinology | volume = 76 | issue = 1 | pages = 28–34 | year = 2002 | pmid = 12097814 | doi = 10.1159/000063681 }}</ref>
* Uni<ref name="pmid16339018">{{cite journal | author = Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J | title = Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors | journal = J Neurosci. | volume = 25 | issue = 49 | pages = 11231–8 | year = 2005 | pmid = 16339018 | doi = 10.1523/JNEUROSCI.1724-05.2005 }}</ref>
* Lämmönsäätely<ref name="pmid9106912">{{cite journal | author = Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL | title = Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists| journal = Psychopharmacology (Berl). | volume = 130 | issue = 2 | pages = 144–51 | year = 1997 | pmid = 9106912 | doi = 10.1007/s002130050222 }}</ref>
* Verisuonten supistuminen<ref name="pmid12654345">{{cite journal | author = Blessing WW, Seaman B. | title = 5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats | journal = Neuroscience. | volume = 117 | issue = 4 | pages = 939–948 | year = 2003 | pmid = 12654345 | doi = 10.1016/S0306-4522(02)00810-2 }}</ref>
|<!--5-HT2A AGONISTs-->
* [[2C-B]]
* [[5-MeO-DMT]]
* [[Bentsyylipiperatsiini|BZP]]
* [[Bufoteniini]]
* [[Dimetyylitryptamiini|DMT]]
* [[2,5-Dimetoksi-4-metyyliamfetamiini|DOM]]
* [[Ergonoviini]]
* [[Lisuridi]]
* [[LSD]]
* [[Meskaliini]]
* [[Myristisiini]]
* [[Psilosiini]]
* [[Psilosybiini]]
* [[TFMPP]] (osittaisagonisti tai antagonisti)
* [[Johimbiini]]
|<!--5-HT2A ANTAGONISTs-->
* [[Epätyypillinen antipsykootti|Epätyypilliset antipsykootit]]
** [[Klotsapiini]]<ref name=pharmamotion/>
** [[Olantsapiini]]
** [[Ketiapiini]]
** [[Risperidoni]]
** [[Tsiprasidoni]]
* [[Aripipratsoli]]
* [[Asenapiini]]
* [[Amitriptyliini]]
* [[Klomipramiini]]
* [[Syproheptadiini]]
* [[Eplivanseriini]]
* [[Etoperidoni]]
* [[Iloperidoni]]
* [[Ketanseriini]]<ref name=pharmamotion/> ([[antihypertensive]]<ref name=pharmamotion/>)
* [[Metysergidi]]
* [[Mianseriini]]
* [[Mirtatsapiini]]
* [[Nefatsodoni]]
* [[Pimavanseriini]]
* [[Pitsotifeeni]]
* [[Ritanseriini]]
* [[Tratsodoni]]
|-
! [[5-HT2B-reseptori|5-HT<sub>2B</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR2B HTR2B]
|
* Verisuonet
* Keskushermosto
* Ruoansulatuskanava
* Verihiutaleet
* Ääreishermosto
* Sileä lihaskudos
|
* Hätääntyneisyys<ref name="pmid8730737">{{cite journal | author = Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP | title = Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety | journal = Br J Pharmacol. | volume = 117 | issue = 7 | pages = 1443–8 | year = 1996 | pmid = 8730737 | pmc = 1909458 }}</ref><ref name="pmid9225285">{{cite journal | author = Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC | title = Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 601–8 | year = 1997 | pmid = 9225285 | doi = 10.1016/S0028-3908(97)00042-7 }}</ref><ref name="pmid9886683">{{cite journal | author = Kennett GA, Trail B, Bright F | title = Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated | journal = Neuropharmacology | volume = 37 | issue = 12 | pages = 1603–10 | year = 1998 | pmid = 9886683 | doi = 10.1016/S0028-3908(98)00115-4 }}</ref>
* Ruokahalu<ref name="pmid9144661">{{cite journal | author = Kennett GA, Ainsworth K, Trail B, Blackburn TP | title = BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats | journal = Neuropharmacology | volume = 36 | issue = 2 | pages = 233–9 | year = 1997 | pmid = 9144661 | doi = 10.1016/S0028-3908(96)00171-2 }}</ref>
* Sydän
* Ruoansulatuskanavan liikkuvuus<ref name="pmid11877320">{{cite journal | author = Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. | title = 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro | journal = Br J Pharmacol. | volume = 135 | issue = 5 | pages = 1144–1151 | year = 2002 | pmid = 11877320 | doi = 10.1038/sj.bjp.0704571 | pmc = 1573235 }}</ref>
* Uni<ref name="pmid16339018"/>
* Verisuonten supistuminen
|<!--5-HT2B AGONISTs-->
* [[BW-723C86]]
* [[Fenfluramiini]]
* [[MDMA]]
* [[Norfenfluramiini]]
* [[Ro60-0175]]
|<!--5-HT2B ANTAGONISTs-->
* [[Agomelatiini]]
* [[Asenapiini]]
* [[Bentsyylipiperatsiini|BZP]]
* [[Ketanseriini]]
* [[Metysergidi]]
* [[Ritanseriini]]
* [[Tegaserodi]]
* [[Johimbiini]]
|-
! [[5-HT2C-reseptori|5-HT<sub>2C</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR2C HTR2C]
|
* Verisuonet
* Keskushermosto
* Ruoansulatuskanava
* Verihiutaleet
* Ääreishermosto
* Sileä lihaskudos
|
* Riippuvuus. (mahdollisesti moduloiva)<ref name="Bubar"/>
* Hätääntyneisyys<ref name="pmid9225286">{{cite journal | author = Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP | title = SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist | journal = Neuropharmacology. | volume = 36 | issue = 4–5 | pages = 609–20 | year = 1997 | pmid = 9225286 | doi = 10.1016/S0028-3908(97)00038-5 }}</ref><ref name="pmid15289999">{{cite journal | author = Millan MJ, Brocco M, Gobert A, Dekeyne A | title = Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade | journal = Psychopharmacology (Berl). | volume = 177 | issue = 4 | pages = 448–58 | year = 2005 | pmid = 15289999 | doi = 10.1007/s00213-004-1962-z }}</ref><ref name="pmid18523738">{{cite journal | author = Millan MJ, Brocco M, Gobert A, Dekeyne A | title = S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models | journal = Psychopharmacology (Berl). | volume = 199 | issue = 4 | pages = 549–68 | year = 2008 | pmid = 18523738 | doi = 10.1007/s00213-008-1177-9 }}</ref>
* Ruokahalu
* Ruoansulatuskanavan liikkuvuus<ref name="pmid19058784">{{cite journal | author = Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A. | title = Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin | journal = Biol Psychiatry. | volume = 65 | issue = 9 | pages = 748–759 | year = 2009 | pmid = 19058784 | doi = 10.1016/j.biopsych.2008.10.031 }}</ref>
* Liikkeet
* Mieliala<ref name="pmid15289999"/><ref name="pmid18523738"/>
* Siittimen erektio<ref name="pmid9151932">{{cite journal | author = Millan MJ, Peglion JL, Lavielle G, Perrin-Monneyron S | title = 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists | journal = Eur J Pharmacol. | volume = 325 | issue = 1 | pages = 9–12 | year = 1997 | pmid = 9151932 | doi = 10.1016/S0014-2999(97)89962-1 }}</ref><ref name="pmid8001637">{{cite journal | author = Stancampiano R, Melis MR, Argiolas A | title = Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission | journal = Eur J Pharmacol. | volume = 261 | issue = 1–2 | pages = 149–55 | year = 1994 | pmid = 8001637 | doi = 10.1016/0014-2999(94)90313-1 }}</ref>
* Seksuaalinen käytös<ref name="pmid12097814"/>
* Uni<ref name="pmid12431861">{{cite journal | author = Frank MG, Stryker MP, Tecott LH | title = Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor | journal = Neuropsychopharmacology | volume = 27 | issue = 5 | pages = 869–73 | year = 2002 | pmid = 12431861 | doi = 10.1016/S0893-133X(02)00353-6 | pmc = 2452994 }}</ref>
* Lämmönsäätely<ref name="pmid9106912"/>
* Verisuonten supistuminen
|<!--5-HT2C AGONISTs-->
* [[A-372,159]]
* [[AL-38022A]]
* [[Aripipratsoli]]
* [[Ergonoviini]]
* [[Lorkaseriini]]
* [[Ro60-0175]]
* [[TFMPP]]
* [[Tratsodoni]]<ref name=pharmamotion/> ([[hypnootti]]<ref name=pharmamotion/>)
* [[YM-348]]
|<!--5-HT2C ANTAGONISTs-->
* [[Agomelatiini]]<ref name=pharmamotion/> ([[antidepressantti]]<ref name=pharmamotion/>)
* [[Amitriptyliini]]
* [[Asenapiini]]
* [[Klomipramiini]]
* [[Klotsapiini]]<ref name=pharmamotion/> ([[antipsykootti]]<ref name=pharmamotion/>)
* [[Syproheptadiini]]
* [[Dimeboliini]]
* [[Eltopratsiini]]
* [[Etoperidoni]]
* [[Fluoksetiini]]
* [[Iloperidoni]]
* [[Ketanseriini]]<ref name=pharmamotion/> ([[antihypertensiivi]]<ref name=pharmamotion/>)
* [[Lisuridi]]
* [[Metysergidi]]<ref name=Rang187>{{cite book |author=Rang, H. P. |title=Pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages= |isbn=0-443-07145-4 |oclc= |doi=}} Page 187</ref>
* [[Mianseriini]]
* [[Mirtatsapine]]
* [[Nefatsodoni]]
* [[Olantsapiini]]
* [[Ketiapiini]]
* [[Risperidoni]]
* [[Ritanseriini]]
* [[Tratsodoni]]
* [[Tsiprasidoni]]
|-
! [[5-HT3-reseptori|5-HT<sub>3</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR3A HTR3A]
* [http://www.genenames.org/data/hgnc_data.php?match=HTR3B HTR3B]
* [http://www.genenames.org/data/hgnc_data.php?match=HTR3C HTR3C]
* [http://www.genenames.org/data/hgnc_data.php?match=HTR3D HTR3D]
* [http://www.genenames.org/data/hgnc_data.php?match=HTR3E HTR3E]
|
* Keskushermosto
* Ruoansulatuskanava
* Ääreishermosto
|
* Riippuvuus
* Hätääntyneisyys
* Oksentaminen
* Ruoansulatuskanavan liikkuvuus
* Oppiminen<ref name="pmid8115433">{{cite journal | author = Pitsikas N, Brambilla A, Borsini F. | title = Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task | journal = Pharmacol Biochem Behav. | volume = 47 | issue = 1 | pages = 95–99 | year = 1994 | pmid = 8115433 | doi = 10.1016/0091-3057(94)90116-3 }}</ref>
* Muisti<ref name="pmid8115433"/>
* Pahoinvointi
|<!--5-HT3 AGONISTs-->
* [[2-metyyli-5-hydroksitryptamiini|2-Metyyli-5-HT]]
* [[Bentsyylipiperatsiini|BZP]]
* [[Kipatsiini]]
* [[RS-56812]]
|<!--5-HT3 ANTAGONISTs-->
* [[Alosetroni]]
* Jotkut [[Antiemeetti|antiemeetit]]<ref name=pharmamotion/>
** [[Dolasetroni]]
** [[Ondansetroni]]<ref name=pharmamotion/>
** [[Granisetroni]]
** [[Tropisetroni]]
* [[Klotsapine]]
* [[Memantiini]]
* [[Metoklopramidi]]
* [[Mianseriini]]
* [[Mirtatsapiini]]
* [[Olantsapiini]]
* [[Ketiapiini]]
|-
! [[5-HT4-reseptori|5-HT<sub>4</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR4 HTR4]
|
* Keskushermosto
* Ruoansulatuskanava
* Ääreishermosto
|
* Hätääntyneisyys<ref name="pmid14676321">{{cite journal | author = Smriga M, Torii K | title = L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats | journal = Proc Natl Acad Sci U S A. | volume = 100 | issue = 26 | pages = 15370–5 | year = 2003 | pmid = 14676321 | doi = 10.1073/pnas.2436556100 | pmc = 307574 }}</ref><ref name="pmid9225297">{{cite journal | author = Kennett GA, Bright F, Trail B, Blackburn TP, Sanger GJ | title = Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 707–12 | year = 1997 | pmid = 9225297 | doi = 10.1016/S0028-3908(97)00037-3 }}</ref>
* Ruokahalu<ref name="pmid17913892">{{cite journal | author = Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V | title = Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens | journal = Proc Natl Acad Sci U S A. | volume = 104 | issue = 41 | pages = 16335–40 | year = 2007 | pmid = 17913892 | doi = 10.1073/pnas.0701471104 | pmc = 2042207 }}</ref><ref name="pmid15146954">{{cite journal | author = J Soc Biol. | title = Compan V, Charnay Y, Dusticier N, Daszuta A, Hen R, Bockaert J | journal = J Soc Biol. | volume = 198 | issue = 1 | pages = 37–49 | year = 2004 | pmid = 15146954 | last2 = Charnay | first2 = Y | last3 = Dusticier | first3 = N | last4 = Daszuta | first4 = A | last5 = Hen | first5 = R | last6 = Bockaert | first6 = J }}</ref>
* Ruoansulatuskanavan liikkuvuus
* Oppiminen<ref name="Meneses A, Hong E 1997 347–51">{{cite journal |author=Meneses A, Hong E |title=Effects of 5-HT4 receptor agonists and antagonists in learning |journal=Pharmacol Biochem Behav |volume=56 |issue=3 |pages=347–51 |year=1997 |pmid=9077568 |doi=10.1016/S0091-3057(96)00224-9}}</ref><ref name="pmid9225295">{{cite journal | author = Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation | journal = Neuropharmacology | volume = 36 | issue = 4–5 | pages = 689–96 | year = 1997 | pmid = 9225295 | doi = 10.1016/S0028-3908(97)00055-5 }}</ref>
* Muisti<ref name="Meneses A, Hong E 1997 347–51"/><ref name="pmid9225295"/><ref name="pmid9732367">{{cite journal | author = Fontana DJ, Daniels SE, Wong EH, Clark RD, Eglen RM | title = Role of 5-HT4 receptors in the mouse passive avoidance test | journal = J Pharmacol Exp Ther. | volume = 286 | issue = 3 | pages = 1115–21 | year = 1998 | pmid = 9732367 }}</ref>
* Mieliala<ref name="pmid17785179">{{cite journal | author = Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G | title = Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action | journal = Neuron | volume = 55 | issue = 5 | pages = 679–81 | year = 2007 | pmid = 17785179 | doi = 10.1016/j.neuron.2007.07.041 }}</ref><ref name="pmid17785173">{{cite journal | author = Duman RS | title = A silver bullet for the treatment of depression? | journal = Neuron | volume = 55 | issue = 5 | pages = 712–25 | year = 2007 | pmid = 17785173 | doi = 10.1016/j.neuron.2007.08.011 | last2 = Rymar | first2 = VV | last3 = Du | first3 = J | last4 = Mnie-Filali | first4 = O | last5 = Bisgaard | first5 = C | last6 = Manta | first6 = S | last7 = Lambas-Senas | first7 = L | last8 = Wiborg | first8 = O | last9 = Haddjeri | first9 = N }}</ref>
* Hengitys<ref name="pmid16166206"/><ref>{{cite journal |author=Manzke T, Guenther U, Ponimaskin E, Haller M, Dutschmann M, Schwarzacher S, Richter D |title=5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia |journal=Science |volume=301 |issue=5630 |pages=226–9 |year=2003 |pmid=12855812 |doi=10.1126/science.1084674}}</ref>
|<!--5-HT4 AGONISTs-->
* [[5-Metokstryptamiini|5-MT]]
* [[BIMU-8]]
* [[Sinitapridi]]
* [[Sisapridi]]<ref name=pharmamotion/> ([[prokineetti]])
* [[Datsopridi]]
* [[Metoklopramidi]]
* [[Mosapridi]]
* [[Prukalopridi]]
* [[RS-67333]]
* [[Rentsapridi]]
* [[Tegaserodi]]
* [[Tsakopridi]]
|<!--5-HT4 ANTAGONISTs-->
* [[L-Lysiini]]<ref name="pmid14676321"/>
* [[Piboserodi]]
|-
![[5-HT5A-reseptori|5-HT<sub>5A</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR5A HTR5A]
|
* Keskushermosto
|
* Liikkeet<ref name="pmid14965244">{{cite journal | author = Nelson DL | title = 5-HT5 receptors | journal = Curr Drug Targets CNS Neurol Disord. | volume =3 | issue = 1 | pages = 53–8 | year = 2004 | pmid = 14965244 | doi = 10.2174/1568007043482606 }}</ref>
* Uni<ref name="pmid15921820">{{cite journal | author = Dietz BM, Mahady GB, Pauli GF, Farnsworth NR | title = Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro | journal = Brain Res Mol Brain Res. | volume = 138 | issue = 2 | pages = 191–7 | year = 2005 | pmid = 15921820 | doi = 10.1016/j.molbrainres.2005.04.009 }}</ref>
|<!--5-HT5A AGONISTs-->
* [[5-Karboksamiditryptamiini|5-CT]]
* [[Ergotamiini]]
* [[Valereenihappo]]<ref name="pmid15921820"/>
|<!--5-HT5A ANTAGONISTs-->
* [[Asenapiini]]
* [[Dimeboliini]]
* [[Metiotepiini]]
* [[Ritanseriini]]
* [[SB-699,551]]
* [[SB-699,551-A]]
|-
! [[5-HT6-reseptori|5-HT<sub>6</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR6 HTR6]
|
* Keskushermosto
|
* Hätääntyneisyys<ref name="pmid18096153">{{cite journal | author = Wesolowska A | title = The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors | journal = European Journal of Pharmacology | volume = 580 | issue = 3 | pages = 355–60 | year = 2008 | month = February | pmid = 18096153 | doi = 10.1016/j.ejphar.2007.11.022 | url = | issn = }}</ref><ref name="pmid17320917">{{cite journal | author = Wesolowska A, Nikiforuk A | title = Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression | journal = Neuropharmacology | volume = 52 | issue = 5 | pages = 1274–83 | year = 2007 | month = April | pmid = 17320917 | doi = 10.1016/j.neuropharm.2007.01.007 | url = | issn = }}</ref>
* Kognitio<ref name="pmid17069795">{{cite journal | author = Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N | title = SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models | journal = European Journal of Pharmacology | volume = 553 | issue = 1–3 | pages = 109–19 | year = 2006 | month = December | pmid = 17069795 | doi = 10.1016/j.ejphar.2006.09.049 | url = | issn = }}</ref>
* Oppiminen<ref name="pmid15964617">{{cite journal | author = Perez-García G, Meneses A | title = Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task | journal = Pharmacology, Biochemistry, and Behavior | volume = 81 | issue = 3 | pages = 673–82 | year = 2005 | month = July | pmid = 15964617 | doi = 10.1016/j.pbb.2005.05.005 | url = | issn = }}</ref>
* Muisti<ref name="pmid15964617"/>
* Mieliala<ref name="pmid17320917"/><ref name="pmid18234190">{{cite journal | author = Wesolowska A, Nikiforuk A | title = The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats | journal = European Journal of Pharmacology | volume = 582 | issue = 1–3 | pages = 88–93 | year = 2008 | month = March | pmid = 18234190 | doi = 10.1016/j.ejphar.2007.12.013 | url = | issn = }}</ref>
|<!--5-HT6 AGONISTs-->
* [[EMD-386,088]]
* [[2-Etyyli-5-metoksi-N,N-dimetyylitryptamiini|EMDT]]
|<!--5-HT6 ANTAGONISTs-->
* [[Amitriptyliini]]
* [[Aripipratsoli]]
* [[Asenapiini]]
* [[Klomipramiini]]
* [[Klotsapiini]]
* [[Dimeboliini]]
* [[EGIS-12233]]
* [[Iloperidoni]]
* [[MS-245]]
* [[Olantsapiini]]
* [[Ro04-6790]]
* [[SB-258,585]]
* [[SB-271,046]]<ref name="titleTarget Schizophrenia - Possible future developments">{{cite web | url = http://www.abpi.org.uk/publications/publication_details/targetSchizophrenia-2003/section5.asp | title = Target Schizophrenia - Possible future developments | accessdate = 2008-04-11 | author = | authorlink = | coauthors = | date = | format = | work = | publisher = The Association of the British Pharmaceutical Industry | pages = | language = |archiveurl = http://web.archive.org/web/20080612135635/http://www.abpi.org.uk/publications/publication_details/targetSchizophrenia-2003/section5.asp <!-- Bot retrieved archive --> |archivedate = 2008-06-12 | quote = }}</ref>
* [[SB-357,134]]
* [[SB-399,885]]
|-
! [[5-HT7-reseptori|5-HT<sub>7</sub>]]
|
* [http://www.genenames.org/data/hgnc_data.php?match=HTR7 HTR7]
|
* Verisuonet
* Keskushermosto
* Ruoansulatuskanava
|
* Hätääntyneisyys<ref name="pmid16018977">{{cite journal | author = Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG | title = 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern | journal = Biological Psychiatry | volume = 58 | issue = 10 | pages = 831–7 | year = 2005 | month = November | pmid = 16018977 | doi = 10.1016/j.biopsych.2005.05.012 | url = | issn = }}</ref><ref name="pmid16828124">{{cite journal | author = Wesolowska A, Nikiforuk A, Stachowicz K, Tatarczynska E | title = Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression | journal = Neuropharmacology | volume = 51 | issue = 3 | pages = 578–86 | year = 2006 | month = September | pmid = 16828124 | doi = 10.1016/j.neuropharm.2006.04.017 | url = | issn = }}</ref>
* Muisti<ref name="pmid18308404">{{cite journal | author = Gasbarri A, Cifariello A, Pompili A, Meneses A | title = Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat | journal = Behavioural Brain Research | volume = 195 | issue = 1 | pages = 164–70 | year = 2008 | month = December | pmid = 18308404 | doi = 10.1016/j.bbr.2007.12.020 | url = | issn = }}</ref><ref name="pmid18570192">{{cite journal | author = Liy-Salmeron G, Meneses A | title = Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model | journal = Hippocampus | volume = 18 | issue = 9 | pages = 965–74 | year = 2008 | pmid = 18570192 | doi = 10.1002/hipo.20459 | url = | issn = }}</ref>
* Mieliala<ref name="pmid16018977"/><ref name="pmid16828124"/>
* Hengitys<ref name="pmid16166206">{{cite journal | author = Meyer LC, Fuller A, Mitchell D | title = Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats | journal = Am J Physiol Regul Integr Comp Physiol. | volume = 290 | issue = 2 | pages = 405–13 | year = 2006 | pmid = 16166206 | doi = 10.1152/ajpregu.00440.2005 }}</ref><ref name="pmid17314195">{{cite journal | author = Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C | title = Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents | journal = J Pharmacol Exp Ther. | volume = 321 | issue = 2 | pages = 690–8 | year = 2007 | pmid = 17314195 | doi = 10.1124/jpet.107.119404 }}</ref>
* Uni<ref name="pmid16018977"/><ref name="pmid17314195"/><ref name="pmid12812993">{{cite journal | author = Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT | title = SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats | journal = Br J Pharmacol. | volume = 139 | issue = 4 | pages = 705–14 | year = 2003 | pmid = 12812993 | doi = 10.1038/sj.bjp.0705290 | pmc = 1573887 }}</ref>
* Lämmönsäätely
* Verisuonten supistuminen
|<!--5-HT7 AGONISTs-->
* [[5-Karboksamiditryptamiini|5-CT]]
* [[8-OH-DPAT]]
* [[AS-19 (yhdiste)|AS-19]]
|<!--5-HT7 ANTAGONISTs-->
* [[Amitriptyliini]]
* [[Aripipratsoli]]
* [[Asenapiini]]
* [[Klomipramiini]]
* [[Klotsapine]]
* [[EGIS-12233]]
* [[Iloperidoni]]
* [[Imipramiini]]
* [[Ketanseriini]]
* [[Mirtatsapiini]]
* [[Olantsapiini]]
* [[Ritanseriini]]
* [[Risperidoni]]
* [[SB-269,970]]
|}

5-HT<sub>1C</sub> -nimistä reseptoria ei ole, koska sellaiseksi alun perin nimetty serotoniinireseptori kloonattiin ja sitä tutkittin tarkemmin, jolloin sillä havaittiin olevan enemmän yhteistä 5-HT<sub>2</sub> -tyypin reseptorien kanssa ja sen uudeksi nimeksi vakiintui 5-HT<sub>2C</sub>. [[5-HT5B-reseptori|5-HT<sub>5B</sub>-reseptori]] on ainoastaan hiirillä ja rotilla, eikä lainkaan ihmisillä tai apinoilla.

Erittäin epäselektiivisiä serotoniiniagonisteja ovat muun maussa [[ergotamiini]] ([[migreeni]]lääke), joka aktivoi 5-HT1A-, 5-HT1D-, 5-HT1B-, D2- ja [[Noradrenaliinireseptori|noradrenaliinireseptoreita]].<ref name=pharmamotion/> LSD ([[psykedeeli]]) on 5-HT1A-, 5-HT2A-, 5-HT2C-, 5-HT5A-, 5-HT5- ja 5-HT6-reseptoreiden agonisti.<ref name=pharmamotion/>

Versio 20. lokakuuta 2011 kello 00.38

[[Tiedosto:Serotonin.svg|thumb|250px|Serotoniini.}} Serotoniinireseptori eli 5-HT-reseptori on monien eliölajien, muun muassa ihmisen reseptori, johon välittäjäaine serotoniini voi kiinnittyä. Reseptoreita on seitsemää tyyppiä, 5-HT1–7, jotka jakautuvat edelleen lukuisiin alatyyppeihin.

Lukuunottamatta 5-HT3-reseptoria, joka on ionikanavareseptori, kaikki muut serotoniinireseptorit ovat G-proteiinikytkentäisiä reseptoreja, jotka aktivoivat toisiolähettejä hermosolun sisällä, jotta viesti välittyy eteenpäin.

Tyypit

Tyyppi Toimintatyyppi Mekanismi Vaikutustapa
5-HT1 Gi/Go-proteiinikytkentäinen. Solun cAMP-tason vähentäminen. Estävä
5-HT2 Gq/G11-proteiinikytkentäinen. Solun IP3- ja DAG-tasojen lisääminen. Kiihdyttävä
5-HT3 Ligandiporttinen Na+ ja K+ -kationikanava. Plasmakalvon depolarisointi. Kiihdyttävä
5-HT4 Gs-proteiinikytkentäinen. Solun cAMP-tason lisääminen. Kiihdyttävä
5-HT5 Gi/Go-proteiinikytkentäinen.[1] Solun cAMP-tason vähentäminen. Estävä
5-HT6 Gs-proteiinikytkentäinen. Solun cAMP-tason lisääminen. Kiihdyttävä
5-HT7 Gs-proteiinikytkentäinen. Solun cAMP-tason lisääminen. Kiihdyttävä

Alatyypit

Päätyypit jakautuvat edelleen alatyyppeihin, joilla on tiettyjä erityisominaisuuksia:[2][3][4]

Yleiskatsaus serotoniinireseptoreista
Reseptori Geeni(t) Sijaintipaikat Tehtävä Agonistit Antagonistit
5-HT1A
  • Verisuonet
  • Keskushermosto
5-HT1B
  • Verisuonet
  • Keskushermosto
5-HT1D
  • Verisuonet
  • Keskushermosto
  • Hätääntyneisyys[35][36]
  • Liikkeet[34]
  • Verisuonten supistuminen
5-HT1e otaksuttu olemassaolevaksi
  • Verisuonet
  • Keskushermosto
5-HT1F
  • Keskushermosto
  • Migreeni
  • LY334370
  • COL-144
5-HT2A
  • Verisuonet
  • Keskushermosto
  • Ruoansulatuskanava
  • Verihiutaleet
  • Ääreishermosto
  • Sileä lihaskudos
  • Riippuvuus (mahdollisesti moduloiva) [37]
  • Hätääntyneisyys[38]
  • Ruokahalu
  • Kognitio
  • Mielikuvitus
  • Oppiminen
  • Muisti
  • Mieliala
  • Havaintokyky
  • Seksuaalinen käytös[39]
  • Uni[40]
  • Lämmönsäätely[41]
  • Verisuonten supistuminen[42]
5-HT2B
  • Verisuonet
  • Keskushermosto
  • Ruoansulatuskanava
  • Verihiutaleet
  • Ääreishermosto
  • Sileä lihaskudos
5-HT2C
  • Verisuonet
  • Keskushermosto
  • Ruoansulatuskanava
  • Verihiutaleet
  • Ääreishermosto
  • Sileä lihaskudos
  • Riippuvuus. (mahdollisesti moduloiva)[37]
  • Hätääntyneisyys[48][49][50]
  • Ruokahalu
  • Ruoansulatuskanavan liikkuvuus[51]
  • Liikkeet
  • Mieliala[49][50]
  • Siittimen erektio[52][53]
  • Seksuaalinen käytös[39]
  • Uni[54]
  • Lämmönsäätely[41]
  • Verisuonten supistuminen
5-HT3
  • Keskushermosto
  • Ruoansulatuskanava
  • Ääreishermosto
  • Riippuvuus
  • Hätääntyneisyys
  • Oksentaminen
  • Ruoansulatuskanavan liikkuvuus
  • Oppiminen[56]
  • Muisti[56]
  • Pahoinvointi
5-HT4
  • Keskushermosto
  • Ruoansulatuskanava
  • Ääreishermosto
5-HT5A
  • Keskushermosto
5-HT6
  • Keskushermosto
5-HT7
  • Verisuonet
  • Keskushermosto
  • Ruoansulatuskanava

5-HT1C -nimistä reseptoria ei ole, koska sellaiseksi alun perin nimetty serotoniinireseptori kloonattiin ja sitä tutkittin tarkemmin, jolloin sillä havaittiin olevan enemmän yhteistä 5-HT2 -tyypin reseptorien kanssa ja sen uudeksi nimeksi vakiintui 5-HT2C. 5-HT5B-reseptori on ainoastaan hiirillä ja rotilla, eikä lainkaan ihmisillä tai apinoilla.

Erittäin epäselektiivisiä serotoniiniagonisteja ovat muun maussa ergotamiini (migreenilääke), joka aktivoi 5-HT1A-, 5-HT1D-, 5-HT1B-, D2- ja noradrenaliinireseptoreita.[28] LSD (psykedeeli) on 5-HT1A-, 5-HT2A-, 5-HT2C-, 5-HT5A-, 5-HT5- ja 5-HT6-reseptoreiden agonisti.[28]

  1. ↑ Francken BJ, Jurzak M, Vanhauwe JF, Luyten WH, Leysen JE. (1998). "The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.". Eur J Pharmacol. 361 (2–3): 299–309. doi:10.1016/S0014-2999(98)00744-4. PMID 9865521. 
  2. ↑ Glennon RA, Dukat M, Westkaemper RB: Serotonin Receptor Subtypes and Ligands 1.1.2000. American College of Neurophyscopharmacology. Viitattu 11.4.2008.
  3. ↑ 5-Hydroxytryptamine Receptors IUPHAR Receptor Database. International Union of Basic and Clinical Pharmacology. Viitattu 11.4.2008.
  4. ↑ Wesolowska A (2002). "In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors" (PDF). Polish Journal of Pharmacology 54 (4): 327–41. PMID 12523486. 
  5. ↑ Tomkins DM, Higgins GA, Sellers EM (1994). "Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake". Psychopharmacology (Berl). 115 (1–2): 173–9. doi:10.1007/BF02244769. PMID 7862892. 
  6. ↑ Müller CP, Carey RJ, Huston JP, De Souza Silva MA (2007). "Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors". Prog Neurobiol. 81 (3): 133–78. doi:10.1016/j.pneurobio.2007.01.001. PMID 17316955. 
  7. ↑ Carey RJ, DePalma G, Damianopoulos E, Shanahan A, Müller CP, Huston JP (2005). "Evidence that the 5-HT1A autoreceptor is an important pharmacological target for the modulation of cocaine behavioral stimulant effects". Brain Res. 1034 (1–2): 162–71. doi:10.1016/j.brainres.2004.12.012. PMID 15713268. 
  8. ↑ a b de Boer SF, Koolhaas JM (2005). "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". Eur J Pharmacol. 526 (1–3): 125–39. doi:10.1016/j.ejphar.2005.09.065. PMID 16310183. 
  9. ↑ Parks CL, Robinson PS, Sibille E, Shenk T, Toth M (1998). "Increased anxiety of mice lacking the serotonin1A receptor". Proc Natl Acad Sci U S A. 195 (18): 10734–9. doi:10.1073/pnas.95.18.10734. PMID 9724773. 
  10. ↑ Ebenezer IS, Arkle MJ, Tite RM (1998). "8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin Pharmacol. 29 (4): 269–72. doi:10.1358/mf.2007.29.4.1075362. PMID 17609739. 
  11. ↑ a b Wouters W, Tulp MT, Bevan P (1998). "Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors". Eur J Pharmacol. 149 (3): 213–23. doi:10.1016/0014-2999(88)90651-6. PMID 2842163. 
  12. ↑ a b Horiuchi J, McDowall LM, Dampney RA (2008). "Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation". Auton Neurosci. 142 (1–2): 71–6. doi:10.1016/j.autneu.2008.06.004. PMID 18667366. 
  13. ↑ Nalivaiko E, Ootsuka Y, Blessing WW. (2005). "Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits". Am J Physiol Regul Integr Comp Physiol. 289 (2): R596–R604. doi:10.1152/ajpregu.00845.2004. PMID 15802554. 
  14. ↑ a b Lucot JB. (1994). "Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin". Eur J Pharmacol. 253 (1–2): 53–60. doi:10.1016/0014-2999(94)90756-0. PMID 8013549. 
  15. ↑ Winstanley CA, Theobald DE, Dalley JW, Robbins TW. (2005). "Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders". Neuropsychopharmacology. 30 (4): 669–682. doi:10.1038/sj.npp.1300610. PMID 15688093. 
  16. ↑ Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, Svenningsson P, Meister B, Kehr J, Stiedl O (2008). "The role of 5-HT(1A) receptors in learning and memory". Behav Brain Res. 195 (1): 54–77. doi:10.1016/j.bbr.2008.02.023. PMID 18394726. 
  17. ↑ Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K (2003). "Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory". Am J Psychiatry 160 (2): 334–40. doi:10.1176/appi.ajp.160.2.334. PMID 12562581. 
  18. ↑ Kennett GA, Dourish CT, Curzon G (1987). "Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression". Eur J Pharmacol. 134 (3): 265–74. doi:10.1016/0014-2999(87)90357-8. PMID 2883013. 
  19. ↑ Bardin L, Tarayre JP, Malfetes N, Koek W, Colpaert FC. (2003). "Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain". Pharmacology. 67 (4): 182–194. doi:10.1159/000068404. PMID 12595749. 
  20. ↑ a b Millan MJ, Perrin-Monneyron S (1997). "Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors". Eur J Pharmacol. 321 (3): 11–3. doi:10.1016/S0014-2999(97)00050-2. PMID 9085055. 
  21. ↑ Prow MR, Martin KF, Heal DJ (1996). "8-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation". Eur J Pharmacol. 317 (1): 21–8. doi:10.1016/S0014-2999(96)00693-0. PMID 8982715. 
  22. ↑ a b c Meyer LC, Fuller A, Mitchell D (February 2006). "Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290 (2): R405–13. doi:10.1152/ajpregu.00440.2005. PMID 16166206.  Viittausvirhe: Virheellinen <ref>-elementti; nimi ”pmid16166206” on määritetty usean kerran eri sisällöillä
  23. ↑ a b Popova NK, Amstislavskaya TG (2002). "Involvement of the 5-HT(1A) and 5-HT(1B) serotonergic receptor subtypes in sexual arousal in male mice". Psychoneuroendocrinology 27 (5): 609–18. doi:10.1016/S0306-4530(01)00097-X. PMID 11965359. 
  24. ↑ Monti JM, Jantos H (1992). "Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat". J Sleep Res. 1 (3): 169–175. doi:10.1111/j.1365-2869.1992.tb00033.x. PMID 10607047. 
  25. ↑ Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS (2007). "A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy")". Neuroscience 146 (2): 509–14. doi:10.1016/j.neuroscience.2007.02.032. PMID 17383105. 
  26. ↑ Gudelsky GA, Koenig JI, Meltzer HY (1986). "Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors". Neuropharmacology 25 (12): 1307–13. doi:10.1016/0028-3908(86)90101-2. PMID 2951611. 
  27. ↑ Ootsuka Y, Blessing WW. (2006). "Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits". Brain Res. 1073-1074: 252–61. doi:10.1016/j.brainres.2005.12.031. PMID 16455061. 
  28. ↑ a b c d e f g h i j k l m n o p q r s t u v pharmamotion.com > Serotonin (5-HT): receptors, agonists and antagonists By Flavio Guzmán, M.D. on 9/08/09
  29. ↑ Harrison AA, Parsons LH, Koob GF, Markou A (1999). "RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist". Psychopharmacology (Berl). 141 (3): 242–50. doi:10.1007/s002130050831. PMID 10027505. 
  30. ↑ Chojnacka-Wójcik E, Klodzinska A, Tatarczynska E (2005). "The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action". J Pharm Pharmacol. 57 (2): 253–7. doi:10.1211/0022357055399. PMID 15720791. 
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  32. ↑ a b Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wójcik E (2004). "Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression". Behav Pharmacol. 15 (8): 523–34. doi:10.1097/00008877-200412000-00001. PMID 15577451. 
  33. ↑ a b Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO (2008). "Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission". Neuropharmacology 54 (7): 1041–50. doi:10.1016/j.neuropharm.2008.02.007. PMID 18394658. 
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  41. ↑ a b Mazzola-Pomietto P, Aulakh CS, Tolliver T, Murphy DL (1997). "Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists". Psychopharmacology (Berl). 130 (2): 144–51. doi:10.1007/s002130050222. PMID 9106912. 
  42. ↑ Blessing WW, Seaman B. (2003). "5-hydroxytryptamine(2A) receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats". Neuroscience. 117 (4): 939–948. doi:10.1016/S0306-4522(02)00810-2. PMID 12654345. 
  43. ↑ Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP (1996). "Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety". Br J Pharmacol. 117 (7): 1443–8. PMID 8730737. 
  44. ↑ Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC (1997). "Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat". Neuropharmacology 36 (4–5): 601–8. doi:10.1016/S0028-3908(97)00042-7. PMID 9225285. 
  45. ↑ Kennett GA, Trail B, Bright F (1998). "Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated". Neuropharmacology 37 (12): 1603–10. doi:10.1016/S0028-3908(98)00115-4. PMID 9886683. 
  46. ↑ Kennett GA, Ainsworth K, Trail B, Blackburn TP (1997). "BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats". Neuropharmacology 36 (2): 233–9. doi:10.1016/S0028-3908(96)00171-2. PMID 9144661. 
  47. ↑ Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. (2002). "5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro". Br J Pharmacol. 135 (5): 1144–1151. doi:10.1038/sj.bjp.0704571. PMID 11877320. 
  48. ↑ Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP (1997). "SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist". Neuropharmacology. 36 (4–5): 609–20. doi:10.1016/S0028-3908(97)00038-5. PMID 9225286. 
  49. ↑ a b Millan MJ, Brocco M, Gobert A, Dekeyne A (2005). "Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade". Psychopharmacology (Berl). 177 (4): 448–58. doi:10.1007/s00213-004-1962-z. PMID 15289999. 
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  71. ↑ Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N (December 2006). "SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models". European Journal of Pharmacology 553 (1–3): 109–19. doi:10.1016/j.ejphar.2006.09.049. PMID 17069795. 
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